Gene: OTUD7A

Alternate names for this Gene: C15orf16|C16ORF15|CEZANNE2|OTUD7

Gene Summary: The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy.

Gene is located in Chromosome: 15

Location in Chromosome : 15q13.3

Description of this Gene: OTU deubiquitinase 7A

Type of Gene: protein-coding

rs1471212 in OTUD7A gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2125623 in OTUD7A gene and Heart failure PMID 20400778 2010 Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.

rs12899987 in OTUD7A gene and Periprosthetic osteolysis PMID 30794219 2019 The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?