Gene: P3R3URF-PIK3R3

Alternate names for this Gene: LOC110117498-PIK3R3

Gene Summary: This locus represents naturally occurring readthrough transcription between the neighboring genes LOC110117498 and PIK3R3. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product.

Gene is located in Chromosome: 1

Location in Chromosome : 1p34.1

Description of this Gene: P3R3URF-PIK3R3 readthrough

Type of Gene: protein-coding

Gene: PIK3R3

Alternate names for this Gene: p55|p55-GAMMA|p55PIK

Gene Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.

Gene is located in Chromosome: 1

Location in Chromosome : 1p34.1

Description of this Gene: phosphoinositide-3-kinase regulatory subunit 3

Type of Gene: protein-coding

rs12142296 in P3R3URF-PIK3R3;PIK3R3 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs1085244 in P3R3URF-PIK3R3;PIK3R3 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1612092 in P3R3URF-PIK3R3;PIK3R3 gene and White Blood Cell Count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.