Gene: PADI4
Alternate names for this Gene: PAD|PAD4|PADI5|PDI4|PDI5
Gene Summary: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
Gene is located in Chromosome: 1
Location in Chromosome : 1p36.13
Description of this Gene: peptidyl arginine deiminase 4
Type of Gene: protein-coding
rs11203366 in
PADI4 gene and
Rheumatoid Arthritis
PMID 21452313 2011 Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.
PMID 21505073 2011 The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.
PMID 23143596 2012 High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
PMID 24532676 2015 High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
PMID 24390342 2014 Genetics of rheumatoid arthritis contributes to biology and drug discovery.
PMID 30423114 2019 Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.