Gene: PALB2

Alternate names for this Gene: FANCN|PNCA3

Gene Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: partner and localizer of BRCA2

Type of Gene: protein-coding

Gene: DCTN5

Alternate names for this Gene: -

Gene Summary: This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: dynactin subunit 5

Type of Gene: protein-coding

rs587776405 in PALB2;DCTN5 gene and Neoplastic Syndromes, Hereditary PMID 24556926 2014 PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.

PMID 25099575 2014 Breast-cancer risk in families with mutations in PALB2.