Gene: PANK1

Alternate names for this Gene: PANK

Gene Summary: This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).

Gene is located in Chromosome: 10

Location in Chromosome : 10q23.31

Description of this Gene: pantothenate kinase 1

Type of Gene: protein-coding

rs11185790 in PANK1 gene and Glucose measurement PMID 19060910 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

rs11185790 in PANK1 gene and Insulin measurement PMID 19060910 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

rs11185790 in PANK1 gene and elevated blood glucose level PMID 19060910 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

rs7073802 in PANK1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.