Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

Gene: CASC19

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

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Description of this Gene:

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rs2466035 in PCAT1;CASC19 gene and Chronic Lymphocytic Leukemia PMID 23770605 2013 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

rs10505483 in PCAT1;CASC19 gene and Malignant neoplasm of prostate PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 19767754 2009 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

PMID 17401366 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

rs16901979 in PCAT1;CASC19 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs10505483 in PCAT1;CASC19 gene and Prostate carcinoma PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.

PMID 26034056 2015 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

PMID 24753544 2014 Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

PMID 17401366 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

PMID 26443449 2015 Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.

PMID 31562322 2019 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.

PMID 25939597 2015 Two susceptibility loci identified for prostate cancer aggressiveness.

PMID 19767754 2009 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

PMID 23104005 2012 A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.

PMID 27262462 2016 Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.

rs2466035 in PCAT1;CASC19 gene and Small Lymphocytic Lymphoma PMID 23770605 2013 Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.