Gene: PCAT1
Alternate names for this Gene: PCA1|PCAT-1|PiHL
Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.
Gene is located in Chromosome: 8
Location in Chromosome : 8q24.21
Description of this Gene: prostate cancer associated transcript 1
Type of Gene: ncRNA
rs1456314 in
PCAT1 gene and
Prostate carcinoma
PMID 17401366 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
PMID 29356057 2018 The 8q24 risk region was also found to be a major contributor to PCa risk in Ugandan men, with the African ancestry-specific risk variant rs72725854 estimated to account for 12% of PCa in this population.
PMID 26034056 2015 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.