Gene: PCAT2

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Gene: PCAT1

Alternate names for this Gene: PCA1|PCAT-1|PiHL

Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: prostate cancer associated transcript 1

Type of Gene: ncRNA

Gene: PRNCR1

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Gene: CASC19

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rs1016343 in PCAT2;PCAT1;PRNCR1;CASC19 gene and Malignant neoplasm of prostate PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.

PMID 21743057 2011 Genome-wide association study identifies new prostate cancer susceptibility loci.

rs1016343 in PCAT2;PCAT1;PRNCR1;CASC19 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs1016343 in PCAT2;PCAT1;PRNCR1;CASC19 gene and Prostate carcinoma PMID 26034056 2015 A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.

PMID 18264097 2008 Multiple newly identified loci associated with prostate cancer susceptibility.

PMID 21743057 2011 Genome-wide association study identifies new prostate cancer susceptibility loci.

PMID 17401366 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.