Gene: PHB

Alternate names for this Gene: HEL-215|HEL-S-54e|PHB1

Gene Summary: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 17

Location in Chromosome : 17q21.33

Description of this Gene: prohibitin

Type of Gene: protein-coding

rs2898883 in PHB gene and Autism Spectrum Disorders PMID 28533516 2018 ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains.

rs2898883 in PHB gene and Child Development Disorders, Pervasive PMID 28533516 2018 ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains.

rs7502499 in PHB gene and Coronary Artery Disease PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

rs7502499 in PHB gene and Malignant Neoplasms PMID 29299148 2017 Cancer risk susceptibility loci in a Swedish population.

rs55714120 in PHB gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs55714120 in PHB gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.