Gene: PHF21A

Alternate names for this Gene: BHC80|BM-006|IDDBCS|NEDMS

Gene Summary: The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010].

Gene is located in Chromosome: 11

Location in Chromosome : 11p11.2

Description of this Gene: PHD finger protein 21A

Type of Gene: protein-coding

rs16938437 in PHF21A gene and Age at menarche PMID 21102462 2010 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs16938437 in PHF21A gene and Body Height PMID 31564439 2019 Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 29782485 2018 Evaluation and application of summary statistic imputation to discover new height-associated loci.

rs79686965 in PHF21A gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11038747 in PHF21A gene and Fatty acid measurement PMID 29738550 2018 Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.

rs2932513 in PHF21A gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs140876547 in PHF21A gene and Venous Thromboembolism PMID 31420334 2019 Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.

rs140273453 in PHF21A gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.