Gene: PIK3CB
Alternate names for this Gene: P110BETA|PI3K|PI3KBETA|PIK3C1
Gene Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 3
Location in Chromosome : 3q22.3
Description of this Gene: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Type of Gene: protein-coding
rs149005978 in
PIK3CB gene and
Smoking
PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
rs149005978 in
PIK3CB gene and
Smoking Behaviors
PMID 26053186 2015 Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.