Gene: PIK3R3

Alternate names for this Gene: p55|p55-GAMMA|p55PIK

Gene Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.

Gene is located in Chromosome: 1

Location in Chromosome : 1p34.1

Description of this Gene: phosphoinositide-3-kinase regulatory subunit 3

Type of Gene: protein-coding

Gene: P3R3URF-PIK3R3

Alternate names for this Gene: LOC110117498-PIK3R3

Gene Summary: This locus represents naturally occurring readthrough transcription between the neighboring genes LOC110117498 and PIK3R3. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product.

Gene is located in Chromosome: 1

Location in Chromosome : 1p34.1

Description of this Gene: P3R3URF-PIK3R3 readthrough

Type of Gene: protein-coding

rs66538782 in PIK3R3;P3R3URF-PIK3R3 gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11211257 in PIK3R3;P3R3URF-PIK3R3 gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs66538782 in PIK3R3;P3R3URF-PIK3R3 gene and Neutrophil count (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.