Gene: PITX3

Alternate names for this Gene: ASGD1|ASMD|ASOD|CTPP4|CTRCT11|PTX3

Gene Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: paired like homeodomain 3

Type of Gene: protein-coding

Gene: ELOVL3

Alternate names for this Gene: CIG-30|CIG30

Gene Summary: This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.32

Description of this Gene: ELOVL fatty acid elongase 3

Type of Gene: protein-coding

rs10786662 in PITX3;ELOVL3 gene and Atrial Fibrillation PMID 29892015 2018 Multi-ethnic genome-wide association study for atrial fibrillation.

rs10786662 in PITX3;ELOVL3 gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 29186694 2017 Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.