Gene: PKN1

Alternate names for this Gene: DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1

Gene Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.12

Description of this Gene: protein kinase N1

Type of Gene: protein-coding