Gene: PLA2G12B

Alternate names for this Gene: FKSG71|GXIIB|GXIIIsPLA2|PLA2G13|sPLA2-GXIIB

Gene Summary: The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants.

Gene is located in Chromosome: 10

Location in Chromosome : 10q22.1

Description of this Gene: phospholipase A2 group XIIB

Type of Gene: protein-coding