Gene: PLA2G2A

Alternate names for this Gene: MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2

Gene Summary: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.13

Description of this Gene: phospholipase A2 group IIA

Type of Gene: protein-coding

rs11573156 in PLA2G2A gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs11573156 in PLA2G2A gene and C-reactive protein measurement PMID 31070471 2019 Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.