Gene: PLA2G3

Alternate names for this Gene: GIII-SPLA2|SPLA2III|sPLA2-III

Gene Summary: This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease.

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.2

Description of this Gene: phospholipase A2 group III

Type of Gene: protein-coding