Gene: PLA2G5

Alternate names for this Gene: FRFB|GV-PLA2|PLA2-10|hVPLA(2)

Gene Summary: This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

Gene is located in Chromosome: 1

Location in Chromosome : 1p36.13

Description of this Gene: phospholipase A2 group V

Type of Gene: protein-coding

rs11573260 in PLA2G5 gene and C-reactive protein measurement PMID 31070471 2019 Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.

rs387906795 in PLA2G5 gene and Fleck Retina, Familial Benign PMID 22137173 2011 Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina.

rs2020887 in PLA2G5 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs10916704 in PLA2G5 gene and Low density lipoprotein cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs10916704 in PLA2G5 gene and Serum LDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs10916704 in PLA2G5 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs576634 in PLA2G5 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.