Gene: PLA2R1

Alternate names for this Gene: CLEC13C|PLA2-R|PLA2G1R|PLA2IR|PLA2R

Gene Summary: This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.2

Description of this Gene: phospholipase A2 receptor 1

Type of Gene: protein-coding

rs2667011 in PLA2R1 gene and Bilirubin measurement PMID 20639394 2010 Genome-wide association of serum bilirubin levels in Korean population.

rs3749117 in PLA2R1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs4664304 in PLA2R1 gene and Crohn Disease PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs3792188 in PLA2R1 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4664304 in PLA2R1 gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs17830558 in PLA2R1 gene and Membranous glomerulonephritis PMID 27333618 2017 In GWAS, lead variants in known loci [rs9272729, HLA-DQA1, odds ratio (OR) = 7.3 per risk allele, P = 5.9 × 10<sup>-27</sup> and rs17830558, PLA2R1, OR = 2.2, P = 1.9 × 10<sup>-8</sup>] were significantly associated with MN.