Gene: PLCH1

Alternate names for this Gene: PLC eta 1|PLC-L3|PLCL3

Gene Summary: PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009].

Gene is located in Chromosome: 3

Location in Chromosome : 3q25.31

Description of this Gene: phospholipase C eta 1

Type of Gene: protein-coding

rs114436839 in PLCH1 gene and Adenocarcinoma of large intestine PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs16825225 in PLCH1 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs114436839 in PLCH1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and Colorectal Carcinoma PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and Colorectal Neoplasms PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and Malignant neoplasm of large intestine PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs114436839 in PLCH1 gene and Malignant tumor of colon PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

rs16825225 in PLCH1 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.