Gene: PLPPR5

Alternate names for this Gene: LPPR5|PAP2|PAP2D|PRG5

Gene Summary: The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene is located in Chromosome: 1

Location in Chromosome : 1p21.3

Description of this Gene: phospholipid phosphatase related 5

Type of Gene: protein-coding

rs79746559 in PLPPR5 gene and Duration of sleep PMID 27126917 2016 Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study.

rs55646170 in PLPPR5 gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.