Gene: PPCDC

Alternate names for this Gene: MDS018|PPC-DC|coaC

Gene Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 15

Location in Chromosome : 15q24.2

Description of this Gene: phosphopantothenoylcysteine decarboxylase

Type of Gene: protein-coding

rs147451859 in PPCDC gene and Breast Carcinoma PMID 31371054 2019 Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer.

rs2120019 in PPCDC gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs4886656 in PPCDC gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12148488 in PPCDC gene and Mean blood pressure PMID 27618448 2016 Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.

rs2120019 in PPCDC gene and Serum zinc measurement PMID 23720494 2013 Genome-wide association study identifies loci affecting blood copper, selenium and zinc.

rs67544533 in PPCDC gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.