Gene: PPM1E

Alternate names for this Gene: CaMKP-N|POPX1|PP2CH|caMKN

Gene Summary: This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.

Gene is located in Chromosome: 17

Location in Chromosome : 17q22

Description of this Gene: protein phosphatase, Mg2+/Mn2+ dependent 1E

Type of Gene: protein-coding

Gene: TRIM37

Alternate names for this Gene: MUL|POB1|TEF3

Gene Summary: This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders.

Gene is located in Chromosome: 17

Location in Chromosome : 17q22

Description of this Gene: tripartite motif containing 37

Type of Gene: protein-coding