Gene: PPP1R1C

Alternate names for this Gene: IPP5

Gene Summary: Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010].

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.3-q32.1

Description of this Gene: protein phosphatase 1 regulatory inhibitor subunit 1C

Type of Gene: protein-coding

rs12474446 in PPP1R1C gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.