Gene: PPP4R1

Alternate names for this Gene: MEG1|PP4(Rmeg)|PP4R1

Gene Summary: This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 18

Location in Chromosome : 18p11.22

Description of this Gene: protein phosphatase 4 regulatory subunit 1

Type of Gene: protein-coding

rs7240432 in PPP4R1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.