Gene: PRB2

Alternate names for this Gene: IB-9|PRPPRB1|Ps|cP7

Gene Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.2

Description of this Gene: proline rich protein BstNI subfamily 2

Type of Gene: protein-coding

Gene: PRB1

Alternate names for this Gene: PM|PMF|PMS|PRB1L|PRB1M

Gene Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Medium' allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.2

Description of this Gene: proline rich protein BstNI subfamily 1

Type of Gene: protein-coding

rs2900174 in PRB2;PRB1 gene and Pancreatic carcinoma PMID 22142827 2012 A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.

PMID 28470677 2017 Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.