Gene: PRICKLE1
Alternate names for this Gene: EPM1B|RILP
Gene Summary: This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Gene is located in Chromosome: 12
Location in Chromosome : 12q12
Description of this Gene: prickle planar cell polarity protein 1
Type of Gene: protein-coding