Gene: PRKD1
Alternate names for this Gene: CHDED|PKC-MU|PKCM|PKD|PRKCM
Gene Summary: The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion.
Gene is located in Chromosome: 14
Location in Chromosome : 14q12
Description of this Gene: protein kinase D1
Type of Gene: protein-coding
rs10136330 in
PRKD1 gene and
Age at menarche
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs72662240 in
PRKD1 gene and
Alopecia
PMID 28196072 2017 Genetic prediction of male pattern baldness.
rs11847697 in
PRKD1 gene and
Body Weight
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
rs10151686 in
PRKD1 gene and
Body mass index
PMID 26604143 2016 Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
rs11847697 in
PRKD1 gene and
Body mass index procedure
PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
rs11847697 in
PRKD1 gene and
Finding of body mass index
PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
rs55906749 in
PRKD1 gene and
Hip circumference
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
rs1959440 in
PRKD1 gene and
Intelligence
PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
rs12589992 in
PRKD1 gene and
Lymphocyte Count measurement
PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
rs225848 in
PRKD1 gene and
Psychosexual dysfunction
PMID 22445761 2012 Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.
rs1959440 in
PRKD1 gene and
Schizophrenia
PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
PMID 31268507 2019 Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
PMID 26198764 2015 Genome-wide association study of schizophrenia in Ashkenazi Jews.
PMID 25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.
PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
rs225848 in
PRKD1 gene and
Sexual Dysfunction
PMID 22445761 2012 Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.
rs17115145 in
PRKD1 gene and
Systolic Pressure
PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
rs11847697 in
PRKD1 gene and
Waist Circumference
PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.