Gene: PRKRA

Alternate names for this Gene: DYT16|HSD14|PACT|RAX

Gene Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.2

Description of this Gene: protein activator of interferon induced protein kinase EIF2AK2

Type of Gene: protein-coding

Gene: CHROMR

Alternate names for this Gene: CHROME|PRKRA-AS1

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.2

Description of this Gene: cholesterol induced regulator of metabolism RNA

Type of Gene: ncRNA

rs121434410 in PRKRA;CHROMR gene and DYSTONIA 16 (disorder) PMID 26990861 2016 PRKRA Mutation Causing Early-Onset Generalized Dystonia-Parkinsonism (DYT16) in an Italian Family.

PMID 25142429 2014 DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family.

PMID 18243799 2008 DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.

PMID 18420150 2008 A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient.

PMID 26231208 2015 Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT.

rs62176107 in PRKRA;CHROMR gene and Dermatitis, Atopic PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs62176107 in PRKRA;CHROMR gene and Psoriasis PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.