Gene: PRNCR1
Alternate names for this Gene:
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Gene: PCAT1
Alternate names for this Gene: PCA1|PCAT-1|PiHL
Gene Summary: This gene produces a long non-coding RNA that promotes cell proliferation and is upregulated in prostate, colorectal, and other cancers. This RNA negatively regulates the BRCA2 tumor suppressor protein and positively regulates Myc oncoprotein. It contains binding sites for microRNAs, and may act as a sponge for microRNAs that regulate cell growth pathways.
Gene is located in Chromosome: 8
Location in Chromosome : 8q24.21
Description of this Gene: prostate cancer associated transcript 1
Type of Gene: ncRNA
Gene: CASC19
Alternate names for this Gene:
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rs1456315 in
PRNCR1;PCAT1;CASC19 gene and
Malignant neoplasm of prostate
PMID 20676098 2010 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
PMID 23023329 2012 Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
PMID 22923026 2012 Evaluating genetic risk for prostate cancer among Japanese and Latinos.
rs1456315 in
PRNCR1;PCAT1;CASC19 gene and
Prostate carcinoma
PMID 20676098 2010 Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
PMID 23023329 2012 Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.