Gene: PRRX2

Alternate names for this Gene: PMX2|PRX2

Gene Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.

Gene is located in Chromosome: 9

Location in Chromosome : 9q34.11

Description of this Gene: paired related homeobox 2

Type of Gene: protein-coding

rs7866070 in PRRX2 gene and Astigmatism PMID 20585627 2010 Web-based, participant-driven studies yield novel genetic associations for common traits.