Gene: PSMA3-AS1

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Gene: PSMA3

Alternate names for this Gene: HC8|PSC3

Gene Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Gene is located in Chromosome: 14

Location in Chromosome : 14q23.1

Description of this Gene: proteasome 20S subunit alpha 3

Type of Gene: protein-coding

Gene: ARMH4

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rs8005100 in PSMA3-AS1;PSMA3;ARMH4 gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.