Gene: PSORS1C1

Alternate names for this Gene: C6orf16|SEEK1

Gene Summary: This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: psoriasis susceptibility 1 candidate 1

Type of Gene: protein-coding

Gene: CDSN

Alternate names for this Gene: HTSS|HTSS1|HYPT2|PSS|PSS1|S

Gene Summary: This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: corneodesmosin

Type of Gene: protein-coding

rs1062470 in PSORS1C1;CDSN gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs1062470 in PSORS1C1;CDSN gene and AIDS, PROGRESSION TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs3095318 in PSORS1C1;CDSN gene and Asthma PMID 27611488 2017 Identification of Four Novel Loci in Asthma in European American and African American Populations.

rs3095324 in PSORS1C1;CDSN gene and Behcet Syndrome PMID 23001997 2012 Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

rs540385376 in PSORS1C1;CDSN gene and Graves Disease PMID 21900946 2011 Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.

rs1062470 in PSORS1C1;CDSN gene and HIV-1, RESISTANCE TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs1062470 in PSORS1C1;CDSN gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 20041166 2009 Common genetic variation and the control of HIV-1 in humans.

PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs78479381 in PSORS1C1;CDSN gene and Oral Ulcer PMID 30837455 2019 Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.

rs4410768 in PSORS1C1;CDSN gene and Takayasu Arteritis PMID 25604533 2015 Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.

rs3094212 in PSORS1C1;CDSN gene and White Blood Cell Count procedure PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.