Gene: PTP4A1

Alternate names for this Gene: HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1

Gene Summary: This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X.

Gene is located in Chromosome: 6

Location in Chromosome : 6q12

Description of this Gene: protein tyrosine phosphatase 4A1

Type of Gene: protein-coding

Gene: LGSN

Alternate names for this Gene: GLULD1|LGS

Gene Summary: This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 6

Location in Chromosome : 6q12

Description of this Gene: lengsin, lens protein with glutamine synthetase domain

Type of Gene: protein-coding

rs2622274 in PTP4A1;LGSN gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.