Gene: PTPN22

Alternate names for this Gene: LYP|LYP1|LYP2|PEP|PTPN22.5|PTPN22.6|PTPN8

Gene Summary: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene is located in Chromosome: 1

Location in Chromosome : 1p13.2

Description of this Gene: protein tyrosine phosphatase non-receptor type 22

Type of Gene: protein-coding

Gene: AP4B1-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

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rs1217413 in PTPN22;AP4B1-AS1 gene and Rheumatoid Arthritis PMID 17159887 2007 Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis.