Gene: PYROXD2

Alternate names for this Gene: C10orf33|FP3420|YUEF

Gene Summary:

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.2

Description of this Gene: pyridine nucleotide-disulphide oxidoreductase domain 2

Type of Gene: protein-coding

Gene: MIR1287

Alternate names for this Gene: MIRN1287|hsa-mir-1287|mir-1287

Gene Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Gene is located in Chromosome: 10

Location in Chromosome : 10q24.2

Description of this Gene: microRNA 1287

Type of Gene: ncRNA

rs17109634 in PYROXD2;MIR1287 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs10883085 in PYROXD2;MIR1287 gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

PMID 21931564 2011 A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.