Gene: QTRT1

Alternate names for this Gene: FP3235|TGT|TGUT

Gene Summary: This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.2

Description of this Gene: queuine tRNA-ribosyltransferase catalytic subunit 1

Type of Gene: protein-coding

rs11085744 in QTRT1 gene and Forced expiratory volume function PMID 30804560 2019 New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

rs892085 in QTRT1 gene and Psoriasis PMID 23143594 2012 Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

PMID 25574825 2015 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.

rs892085 in QTRT1 gene and Psoriasis vulgaris PMID 26626624 2015 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

rs11085744 in QTRT1 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.