Gene: RABGEF1

Alternate names for this Gene: RABEX5|RAP1|rabex-5

Gene Summary: RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010].

Gene is located in Chromosome: 7

Location in Chromosome : 7q11.21

Description of this Gene: RAB guanine nucleotide exchange factor 1

Type of Gene: protein-coding

rs10215516 in RABGEF1 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.