Gene: RAD23A

Alternate names for this Gene: HHR23A|HR23A

Gene Summary: The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.13

Description of this Gene: RAD23 homolog A, nucleotide excision repair protein

Type of Gene: protein-coding

rs2974755 in RAD23A gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs45495792 in RAD23A gene and Drug-induced neutropenia PMID 25187353 2014 Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.