Gene: RAD51D

Alternate names for this Gene: BROVCA4|R51H3|RAD51L3|TRAD

Gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene.

Gene is located in Chromosome: 17

Location in Chromosome : 17q12

Description of this Gene: RAD51 paralog D

Type of Gene: protein-coding

Gene: RAD51L3-RFFL

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

rs1057521922 in RAD51D;RAD51L3-RFFL gene and BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 4 PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 10749867 2000 Evidence for simultaneous protein interactions between human Rad51 paralogs.

PMID 21111057 2011 Structural and functional characterization of the N-terminal domain of human Rad51D.

PMID 19327148 2009 Functional characterization and identification of mouse Rad51d splice variants.

PMID 14704354 2004 Domain mapping of the Rad51 paralog protein complexes.

PMID 26720727 2016 Use of 5-Hydroxytryptophan Labeled With Carbon 11 in Social Anxiety Disorder.

PMID 26720728 2016 Inherited Mutations in Women With Ovarian Carcinoma.

PMID 21822267 2011 Germline mutations in RAD51D confer susceptibility to ovarian cancer.

PMID 28724667 2017 Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients.

PMID 26845104 2016 Improving performance of multigene panels for genomic analysis of cancer predisposition.

PMID 16717288 2006 Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.

PMID 22986143 2012 Loss of function germline mutations in RAD51D in women with ovarian carcinoma.

PMID 28646019 2017 Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma.

PMID 26976419 2016 Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 25186627 2015 Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 24130102 2014 About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 27083178 2016 Frequency of germline DNA genetic findings in an unselected prospective cohort of triple-negative breast cancer patients participating in a platinum-based neoadjuvant chemotherapy trial.

PMID 27433846 2016 Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

PMID 27153395 2016 Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.

PMID 28008555 2017 Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.

PMID 23372765 2013 Analysis of RAD51D in ovarian cancer patients and families with a history of ovarian or breast cancer.

PMID 22652533 2012 A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer.

rs370228071 in RAD51D;RAD51L3-RFFL gene and Hereditary Breast and Ovarian Cancer Syndrome PMID 22986143 2012 Loss of function germline mutations in RAD51D in women with ovarian carcinoma.

PMID 26845104 2016 Improving performance of multigene panels for genomic analysis of cancer predisposition.

PMID 21822267 2011 Germline mutations in RAD51D confer susceptibility to ovarian cancer.

PMID 28646019 2017 Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 26976419 2016 Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

PMID 26659639 2016 Multilocus Inherited Neoplasia Alleles Syndrome: A Case Series and Review.

PMID 28423363 2017 Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer.

PMID 27083178 2016 Frequency of germline DNA genetic findings in an unselected prospective cohort of triple-negative breast cancer patients participating in a platinum-based neoadjuvant chemotherapy trial.

PMID 20665887 2010 The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations.

PMID 24240112 2014 Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

PMID 24130102 2014 About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

rs1057521922 in RAD51D;RAD51L3-RFFL gene and Neoplastic Syndromes, Hereditary PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 26261251 2015 Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.

PMID 26720728 2016 Inherited Mutations in Women With Ovarian Carcinoma.

PMID 21822267 2011 Germline mutations in RAD51D confer susceptibility to ovarian cancer.

PMID 29020732 2018 Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-gene Panels: Beyond BRCA1/2.

PMID 26046366 2015 Individualized iterative phenotyping for genome-wide analysis of loss-of-function mutations.

PMID 22275364 2012 RAD51 protein ATP cap regulates nucleoprotein filament stability.

PMID 26976419 2016 Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

PMID 24139550 2013 Germline mutation in the RAD51B gene confers predisposition to breast cancer.

PMID 28646019 2017 Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma.

PMID 16717288 2006 Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.

PMID 22986143 2012 Loss of function germline mutations in RAD51D in women with ovarian carcinoma.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 28423363 2017 Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer.

PMID 26057125 2015 Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PMID 24130102 2014 About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.

PMID 25445424 2015 Breast cancer in a RAD51D mutation carrier: case report and review of the literature.

PMID 27083178 2016 Frequency of germline DNA genetic findings in an unselected prospective cohort of triple-negative breast cancer patients participating in a platinum-based neoadjuvant chemotherapy trial.

PMID 24240112 2014 Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

PMID 16236763 2005 The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C.

PMID 6329717 1982 Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

PMID 23372765 2013 Analysis of RAD51D in ovarian cancer patients and families with a history of ovarian or breast cancer.

PMID 26296696 2015 Rescreening for genetic mutations using multi-gene panel testing in patients who previously underwent non-informative genetic screening.

PMID 28008555 2017 Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.