Gene: RARG

Alternate names for this Gene: NR1B3|RARC

Gene Summary: This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 12

Location in Chromosome : 12q13.13

Description of this Gene: retinoic acid receptor gamma

Type of Gene: protein-coding

rs2229774 in RARG gene and Cardiotoxicity PMID 26237429 2015 A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.

rs3741434 in RARG gene and Intelligence PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs2229774 in RARG gene and Malignant Childhood Neoplasm PMID 26237429 2015 A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.

rs3741434 in RARG gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs11170481 in RARG gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.