Gene: RCHY1

Alternate names for this Gene: ARNIP|CHIMP|PIRH2|PRO1996|RNF199|ZCHY|ZNF363

Gene Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4q21.1

Description of this Gene: ring finger and CHY zinc finger domain containing 1

Type of Gene: protein-coding

rs1841932 in RCHY1 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

rs13137105 in RCHY1 gene and Rheumatoid Arthritis PMID 22491018 2013 Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.