Gene: RHOC

Alternate names for this Gene: ARH9|ARHC|H9|RHOH9

Gene Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene is located in Chromosome: 1

Location in Chromosome : 1p13.2

Description of this Gene: ras homolog family member C

Type of Gene: protein-coding