Gene: RHOU

Alternate names for this Gene: ARHU|CDC42L1|G28K|WRCH1|hG28K

Gene Summary: This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.

Gene is located in Chromosome: 1

Location in Chromosome : 1q42.13

Description of this Gene: ras homolog family member U

Type of Gene: protein-coding

rs41271473 in RHOU gene and Chronic Lymphocytic Leukemia PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

rs41271473 in RHOU gene and Small Lymphocytic Lymphoma PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.