Gene: RNASEL

Alternate names for this Gene: PRCA1|RNS4

Gene Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.

Gene is located in Chromosome: 1

Location in Chromosome : 1q25.3

Description of this Gene: ribonuclease L

Type of Gene: protein-coding

rs12736689 in RNASEL gene and Circadian Rhythms PMID 26835600 2016 GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.

PMID 27494321 2016 Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

rs533259 in RNASEL gene and Multiple Sclerosis PMID 23412934 2013 A genome-wide association study of brain lesion distribution in multiple sclerosis.