Gene: RNASET2

Alternate names for this Gene: RNASE6PL|bA514O12.3

Gene Summary: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.

Gene is located in Chromosome: 6

Location in Chromosome : 6q27

Description of this Gene: ribonuclease T2

Type of Gene: protein-coding

rs2149085 in RNASET2 gene and Crohn Disease PMID 23850713 2014 Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.

rs3777722 in RNASET2 gene and Fetal Membranes, Premature Rupture PMID 25599974 2015 A genome-wide association study of early spontaneous preterm delivery.

rs121918137 in RNASET2 gene and Leukoencephalopathy, Cystic, Without Megalencephaly PMID 21199949 2011 rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.

PMID 19525954 2009 RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.

rs2093415 in RNASET2 gene and Lymphocyte Count measurement PMID 22286170 2012 The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.

rs2236313 in RNASET2 gene and Vitiligo PMID 20526339 2010 Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.

PMID 27723757 2016 Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.