Gene: RNF123

Alternate names for this Gene: FP1477|KPC1

Gene Summary: The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: ring finger protein 123

Type of Gene: protein-coding

Gene: MST1

Alternate names for this Gene: D3F15S2|DNF15S2|HGFL|MSP|NF15S2

Gene Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: macrophage stimulating 1

Type of Gene: protein-coding