Gene: RNF5

Alternate names for this Gene: RING5|RMA1

Gene Summary: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: ring finger protein 5

Type of Gene: protein-coding

Gene: AGPAT1

Alternate names for this Gene: 1-AGPAT1|G15|LPAAT-alpha|LPAATA

Gene Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: 1-acylglycerol-3-phosphate O-acyltransferase 1

Type of Gene: protein-coding

Gene: MIR6833

Alternate names for this Gene: hsa-mir-6833

Gene Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.32

Description of this Gene: microRNA 6833

Type of Gene: ncRNA

rs3130349 in RNF5;AGPAT1;MIR6833 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.