Gene: RNF7
Alternate names for this Gene: CKBBP1|ROC2|SAG|rbx2
Gene Summary: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene is located in Chromosome: 3
Location in Chromosome : 3q23
Description of this Gene: ring finger protein 7
Type of Gene: protein-coding
rs16851720 in
RNF7 gene and
Hepatitis C
PMID 22841784 2012 In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients who received blood transfusions) were associated with fibrosis progression (P(combined) = 8.9 × 10(-9) and 1.1 × 10(-9), respectively).
rs16851720 in
RNF7 gene and
Liver Cirrhosis
PMID 22841784 2012 Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.