Gene: ROBO2

Alternate names for this Gene: SAX3

Gene Summary: The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 3

Location in Chromosome : 3p12.3

Description of this Gene: roundabout guidance receptor 2

Type of Gene: protein-coding

rs1523768 in ROBO2 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11709706 in ROBO2 gene and Circadian Rhythms PMID 26835600 2016 GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.

rs190591447 in ROBO2 gene and Interleukin 16 Measurement PMID 27989323 2017 Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

rs775766 in ROBO2 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs12497518 in ROBO2 gene and Prostate carcinoma PMID 27515689 2016 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer.

rs267607014 in ROBO2 gene and Vesicoureteral Reflux 2 PMID 17357069 2007 Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

rs11927597 in ROBO2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.